A Soft and Stretchable Multielectrode Cuff for Selective Peripheral Nerve Stimulation

Bioelectronic medicine can treat diseases and disorders in humans by electrically interfacing with peripheral nerves. Multielectrode cuffs be used for selective stimulation of portions the nerve, which is advantageous treatment specificity. The biocompatibility conformability improved reducing mechanical mismatch between nerve tissue cuffs, but nerves has yet to achieved soft stretchable cuff electrodes. Here, this paper reports development a multielectrode (sMEC) stimulation. device made 50 µm thick silicone embedded gold nanowire conductors, renders it functional at 50% strain, provides superior wrapping By using different protocols, high selectivity sMEC's eight electrodes porcine sciatic model. Finite element modeling predict potential distribution within correlate well results. Recent studies are showing that softness outermost importance foreign body response. It therefore believed high-performance sMEC technology ideal future interfaces bioelectronic medicine.